When asked which guidance would be most useful, researchers often respond that they would benefit from advice on trial design. In response to this need, there is a series of papers being developed by collaborators who are experienced investigators in tropical diseases. The aim with each paper is to offer the best current design approach for assessing new treatments for each of the diseases that have been initially selected. Example protocols, other tools and documents will also be provided here.

The first example will be a paper on conducting trials on visceral leishmaniasis. This will be coordinated by the Drugs for Neglected Diseases initiative; this paper is currently being drafted and is entitled:

‘Evaluating new treatments for visceral leishmaniasis: optimal design and set up guidance for a phase II trial’

The aim is to then follow with these papers:

  1. Evaluating new treatments for malaria: Optimal design and set up guidance for a phase II trial
  2. Evaluating new treatments for tuberculosis in tropical regions: Optimal design and set up guidance for a phase II trial
  3. Evaluating new treatments for diarrhoeal disease in tropical regions: Optimal design and set up guidance for a phase II trial
  4. Evaluating new treatments for dengue: Optimal design and set up guidance for a phase II trial
  5. Evaluating new treatments for influenza in tropical regions: Optimal design and set up guidance for a phase II trial

We invite researchers to get in touch if they wish to take part in writing these papers and welcome suggestions for further diseases/topics.

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