Course Overview

Duration:

The CREDO Statistics module should take approximately 2-3 hours to complete.

Certification:

A certificate is issued once a minimum of 80% is achieved in the final quiz section.

Summary:

This module is complementary to the CREDO – Study Design module. It provides a background of statistical principles relevant to clinical research and trial design and highlights some of the statistical challenges that may occur with trial designs such as adaptive trial designs which may be used in clinical research during an outbreak.

An overview of different clinical research study designs is explained in the CREDO – Study Design module; as such this module cannot be done as a stand-alone module. You will need to refer continuously to the CREDO – Study Design module to better relate to the principles described herein. 

Intended Learning Objectives:

By the end of the module, participants should be able to:

  1. Describe the key statistical issues relevant to clinical trials in epidemic settings. 
  2. Identify issues to consider when designing a trial, including defining outcomes, carrying out sample size calculation, and analysing trial data.

Acknowledgements

This module was compiled by Nzelle Delphine Kayem - Research Associate, Centre for Tropical Medicine & Global Health, University of Oxford, UK;

Course Reviewers and Editors

  • Munyaradzi Dimairo - Research Fellow in Medical Statistics and Project Lead, The ACE Project, University of Sheffield.
  • Eric Ohuma - Senior Medical Statistician, Centre for Statistics in Medicine and Centre for Tropical Medicine and Global Health, University of Oxford.

Course Developer: Nzelle Delphine Kayem - Research Associate, Centre for Tropical Medicine & Global Health, University of Oxford, UK.

Funder: CREDO is funded by TDR, the Special Programme for Research and Training in Tropical Diseases. TDR is a global programme of scientific collaboration that helps facilitate, support and influence efforts to combat diseases of poverty. It is hosted at the World Health Organization (WHO), and is sponsored by the United Nations Children’s Fund (UNICEF), the United Nations Development Programme (UNDP), the World Bank and WHO. The Global Health Training Centre is built through the support and partnership of the Bill and Melinda Gates Foundation, the World-Wide Antimalarial Resistance Network and the East African Consortium for Clinical Research.  

Use and reproduction of these e-learning materials:

These e-learning materials are owned by CREDO. You are free to share or adapt this material but you must attribute it to CREDO using the link https://isaric.tghn.org/credo/